SUDHANSHU SHEKHAR

Most genetic variants linked to disease lie in non-coding DNA. For most of them, we do not know which gene they affect, in which cell type, or how. Closing this gap between genetic association and biological mechanism is central to my research.

I trained in human statistical genetics. My PhD was at Purdue University with Dr. Peristera Paschou. I then did postdoctoral work at UNC Chapel Hill and the University of Cambridge. Across these positions, I studied the genetics of Tourette syndrome and myasthenia gravis. I used TWAS, PWAS, and Mendelian randomization to move from risk loci to candidate genes and proteins. I built TWAS models for immune cell subtypes using single-cell data. I also developed an analysis pipeline for massively parallel reporter assays (MPRA) to find which variants are functional.

At the University of North Texas, I have turned to cancer. Lung cancer cells release extracellular vesicles that can influence the immune system. I study how these vesicles shape anti-tumor immunity and response to immunotherapy. I am also developing aptamer-siRNA therapeutics to target the pathways involved.

Computation and experiments work together in my research. Computational analysis tells me which hypotheses to test. Experiments show which statistical signals are biologically real.

Beyond the lab, I mentor students and take part in STEM outreach to underserved communities. I welcome conversations about collaboration.